Skulltrail is the successor to Intel’s media creation platform V8, and while V8 was certainly powerful, Skulltrail is meant to fix all of the flaws that V8 suffered from. First of all, the motherboard only had one PCIe x16 slot, which means no multi-GPU support. Second, it was more or less impossible to overclock it due to BIOS restrictions (although, you could set the altitude!). Skulltrail supports multiple GPUs, even Quad SLI in fact, and you can overclock the processors now. To get the most out of your Skulltrail, Intel recommends two Intel Core 2 Extreme QX9775, which is basically a socket 771 3.2 GHz Xeon with desktop optimizations and a 1600 MHz FSB.
Over at Firingsquad they’ve published a preview of Skulltrail where they do a quick walkthrough of the features of the motherboard and some share some basic info on the processors. They’ve also published a 3DMark 06 benchmark with the processors running at 4.4 GHz water-cooled, and a CPU score of 7,562 points. The problem is that 3DMark 06 doesn’t really scale beyond four cores, but it’s still damn good.